Process of producing purified gamma- and delta-tocotrienols from tocol-rich oils or distillates

摘要

The invention is generally directed to a process of producing purified gamma- and/or delta-tocotrienols from tocol-rich oils or distillates, such as rice bran oil deodorizer distillate or palm oil. The process produces a gamma- and/or delta-tocotrienol-rich fraction in a high proportion of γ-T3 and/or δ-T3 while minimizing the presence of alpha isomers from the tocol-rich oil or distillate. The γ-T3- and/or δ-T3-rich fraction comprises about 95% of total tocols, with the process yielding γ-T3 in approximately 10% and δ-T3 in about 3%, with each having purity in excess of approximately 95%. The process utilizes flash or other low pressure chromatography to provide rapid isolation of gamma- and/or delta-tocotrienol from the tocol-rich oil or distillate.

主权项

1. A process of producing a gamma- and/or delta-tocotrienol-rich fraction from a tocol-rich oil, said process comprising the steps of:
distilling said tocol-rich oil to produce a tocol concentrate; and purifying said tocol concentrate using flash chromatography with a binary mobile phase gradient comprising hexane-acetic acid (99.1:0.9 v/v) and ethyl acetate-acetic acid (99.1:0.9 v/v) for between about 50 minutes and about 55 minutes to produce said gamma- and/or delta-tocotrienol-rich fraction.