METHOD FOR PRODUCING 4-[5-(PYRIDIN-4-YL)-1H-1,2,4-TRIAZOL-3-YL]PYRIDINE-2-CARBONITRILE

摘要

The invention relates to a method for producing 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile of formula (1): (see formula 1) the method comprising reacting a compound of formula (2): (see formula 2) with isonicotinic acid hydrazide in the presence of an alkali metal alkoxide, to thereby form a compound of formula (3): (see formula 3) cyanating the compound (3) with at least one cyanating agent selected from the group consisting of an alkali metal cyanide, zinc cyanide, and a trialkyl cyanide, to thereby form a compound of formula (4): (see formula 4) and subjecting the compound (4) to a ring-closure reaction in the presence of at least one acid catalyst selected from the group consisting of an organic acid catalyst and an inorganic acid catalyst.