| 摘要 |
A device permitting the progressive and programmed release of one or more active substances or ingredients, characterised in that it can be obtained by: (a) preparing a powder comprising a polymer or resin matrix in which there is at least one suitable plasticiser which is completely absorbed, by spraying the said preheated plasticiser hot onto the said matrix whose temperature is maintained, so as to saturate the said resin while plasticising it; (b) cooling the powder obtained in (a) to a temperature below 30 DEG C; (c) mixing the powder obtained in (b) with at least 5% of at least one carrier of the active ingredient, in the cold state; then (d) adding the active ingredient(s); and (e) bringing the powder obtained in (d) into a suitable form, by any suitable means, which device releases the active ingredient uniformly and completely. The said device can furthermore comprise a polymer sleeve which is impervious to the active ingredient(s) and partly covers the surface of the device. Preparation process for the said device, and applications to the preparation of pharmaceuticals which can be administered orally, to the preparation of pharmaceuticals which can be administered by contact with the skin, and to the preparation of anti-parasite collars. |
