HETEROCYCLIC AMINO COMPOUNDS

摘要

Compounds are disclosed of formula (I): wherein R is hydrogen, or C1-6 alkyl, C1-6 alkyl substituted by C3-7 cycloalkyl, C3-6 alkenyl, C3-6 alkynyl, C3-7 cycloalkyl, or aralkyl (in which the alkyl moiety contains 1 to 5 carbon atoms); and R<1> and R<2>, each independently represents fluorine or chlorine or one of R<1> and R<2> represents hydrogen; and the physiologically acceptable salts thereof. The compounds have a selective alpha 2-adrenorceptor antagonist action and are potentially useful for the treatment of disorders such as depression. The compounds may be prepared, for example by amination of a compound of formula (II): where X is a leaving group, with ammonia or an appropriate amine.