| 摘要 |
Compounds of the formula (1) : <CHEM> and pharmaceutically acceptable salts thereof are described wherein R<1> is C1-6alkyl, C2-6alkenyl, C3-5cycloalkylC1-6alkyl, phenylC1-6alkyl or C1-6alkyl substituted by 1 to 6 fluoro groups; and R<2> is C1-6alkyl, phenyl, hydroxy, C1-6alkoxy, halo, -NHCOR<3>, -NHCONHR<4>, 5-tetrazolyl, -CO2R<5>, cyano, -CONR<6>R<7>, or -NR<8>R<9> wherein R<3> to R<7> are independently hydrogen or C1-6alkyl and R<8> and R<9> are independently hydrogen or C1-6alkyl optionally substituted by hydroxy provided that the carbon atom adjacent to the nitrogen atom is not substituted by hydroxy. Processes for their preparation, pharmaceutical compositions comprising them and their use as medicaments are also described. |
