发明名称 |
A CONTRACTILE CELLULAR CONSTRUCT FOR CELL CULTURE |
摘要 |
The present invention relates to a method for producing a contractile cellular construct, comprising the steps of: a) seeding pre-selected cells onto a mold, wherein the pre-selected cells comprise signal emitting agents; and b) culturing the pre-selected cells to produce the cellular construct. The said method is exemplified by mixing cardiomyocytes with fluorescent microbeads, seeding the suspension on a polydimethylsiloxane (PDMS) mold and culturing to form a contractile device comprising of cardiac muscles. The present invention also relates to a method for measuring the contractility of the cellular construct by measuring the displacement of the signal emitting agents, and a method for screening a method for screening one or more agents for modulating the contractility of a contractile cellular construct. |
申请公布号 |
WO2016186577(A1) |
申请公布日期 |
2016.11.24 |
申请号 |
WO2016SG50228 |
申请日期 |
2016.05.16 |
申请人 |
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH |
发明人 |
LU, Hong Fang;LEONG, Meng Fatt;LIM, Tze Chiun;WAN, Andrew Chwee Aun |
分类号 |
C12N5/077;G01N33/50 |
主分类号 |
C12N5/077 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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