| 摘要 |
Polyelectrolyte membrane capsule comprises a semipermeable membrane (A) and enclosed active material. (A) consists of a biocompatible, non-toxic polyacid (A1) and a polybase (A2) which is a polymer formed from repeating monomer units of formula (I), with R1 and R2 same or different in the various units. (R1 = H or Me; R2 = CH2NH2, imidazolyl or gp. (i); R3 = H, Me or Et). (A2) may include (a) additional, hydrophilic, compatible, uncharged monomer (II) units and (b) additional, water-soluble, biocompatible polymers (A3) which can be crosslinked to (A2). Pref. (A3) are condensation products of HOOC-(CH2)n-COOH (n = 0-8) and NH2-CH2-(CH2-NH-CH2)m-CH2NH2 (m = 1-4), and can be crosslinked with (A2) by using epichlorohydrin. Suitable uncharged monomers are N-vinylpyrrolidone; N-vinyl-methylacetamide and/or vinylcaprolactam.
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| 申请人 |
HOECHST AG, 6230 FRANKFURT, DE |
发明人 |
BADER, DR., HUBERT, W-6500 MAINZ, DE;KEIL, DR., KARL-HEINZ, W-6450 HANAU 6, DE;RUEPPEL, DR., DIETHER, W-6230 FRANKFURT AM MAIN 80, DE;SCHLINGMANN, PROF. DR., MERTEN, W-6240 KOENIGSTEIN/TAUNUS, DE;WALCH, DR., AXEL, W-6000 FRANKFURT AM MAIN 90, DE |
