发明名称 |
ANTIGEN-PRESENTERENDE KAPSID MED FUSERT MS2-KAPPEPROTEIN |
摘要 |
PCT No. PCT/GB92/00124 Sec. 371 Date Nov. 8, 1993 Sec. 102(e) Date Nov. 8, 1993 PCT Filed Jan. 22, 1992 PCT Pub. No. WO92/13081 PCT Pub. Date Aug. 6, 1992.A chimaeric protein, suitable for incorporation in a vaccine and capable of forming parts of a capsid assembly, comprises the amino acid sequence of the coat protein of phage MS-2, or a conservatively modified variant thereof, or sufficient of said sequence or variant to retain capsid-forming capability, which amino acid sequence has been modified by insertion of a foreign epitope in the region corresponding to a protuberant protein hairpin in the capsid assembly as shown in the crystal structure of the intact phage.
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申请公布号 |
NO932644(A) |
申请公布日期 |
1993.09.23 |
申请号 |
NO19930002644 |
申请日期 |
1993.07.22 |
申请人 |
BRITISH TECHNOLOGY GROUP PLC |
发明人 |
MASTICO, ROBERT ALLAN;STOCKLEY, PETER GEORGE;TALBOT, SIMON JOHN |
分类号 |
A61K39/00;A61K39/145;A61K39/21;A61K39/385;A61P31/16;A61P31/18;C07K14/00;C07K14/08;C07K14/11;C07K14/16;C07K16/00;C07K19/00;C12N1/21;C12N15/09;C12N15/10;C12N15/13;C12N15/33;C12N15/44;C12N15/49;C12N15/70;C12P21/02;C12R1/19;C40B40/02;(IPC1-7):C12N15/70;C12N15/62;C12N15/40 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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