| 摘要 |
Mouse animal models are provided for studying lipid metabolism defects and the indications resulting therefrom. Specific genes associated with lipid metabolism are targeted for inactivation by homologous recombination, particularly apoE, apoAI, apoB, apoCIII and hepatic lipase, and homozygous mice are produced, competent to retain the defect in the germ line. The resulting mice may be used for the study of lipid metabolic disorders, as well as the effect of drugs on the disorders and the genetic defect. |
