摘要 |
FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: invention relates to the new derivatives of azole of the general formula (I): <EMI ID=0.201 HE=18 WI=57 TI=CHI> where Ar -halide; R<SP>1</SP> - - hydrogen or lower alkyl; R<SP>3</SP> - - lower alkyl possibly substituted with lower alkyl, halide, trifluoromethyl, lower alkoxy, halide (lower)-alkoxy, piperazinyl, benzylpiperazinyl, lower acylpiperazinyl, lower alkoxyphenylpiperazinyl being alkyl moiety of that can be substituted with halide, and Y and Z are independently nitrogen atom or methyne-group that can be optionally substituted additionally with lower alkyl-group, or its acid-additive salts exhibiting antifungal activity, and pharmaceutical composition based on thereof. The indicated compounds are synthesized by interaction of compounds of the formula (II) <EMI ID=0.202 HE=18 WI=48 TI=CHI> and (III) <EMI ID=0.203 HE=15 WI=12 TI=CHI>. The synthesized compounds can be used in medicine. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 29 cl, 34 tbl, 75 exd |