VESICULAR STOMATITIS VIRUS

摘要

PROBLEM TO BE SOLVED: To provide a method for using a vesicular stomatitis virus for treating cancer.SOLUTION: Provided is a vesicular stomatitis virus comprising an RNA molecule. The RNA molecule comprises a nucleic acid sequence being a template of a positive sense transcript encoding VSN N polypeptide from 3' to 5' direction, a nucleic acid sequence being a template of a positive sense transcript encoding VSN P polypeptide, a nucleic acid sequence being a template of a positive sense transcript encoding VSN G polypeptide, a nucleic acid sequence being a template of a positive sense transcript encoding NIS polypeptide, and a nucleic acid sequence being a template of a positive sense transcript encoding VSN L polypeptide. Also provide is a pharmaceutical composition comprising the vesicular stomatitis virus for inducing tumor regression in a mammal.SELECTED DRAWING: Figure 1