歯周炎原因細胞の特定方法、歯周炎治療薬のスクリーニング方法、歯周炎の検査方法、検査キット

摘要

Established are an analysis of markers of aggressive fibroblasts which are cells that cause periodontitis, screening of novel periodontitis therapeutics, a test method, and a test kit. As a result of analyzing aggressive fibroblasts, it has become apparent that expression from the P1 promoter of RUNX2 and expression of DLX5 are decreased to a greater extent than in normal gingival fibroblasts. An increase in expression of FLT1 was also seen. Using these expressions characteristic of aggressive fibroblasts as markers makes possible the identification of aggressive fibroblasts, a method for screening therapeutics, and a test method.