发明名称 |
COPOLYMER INCLUDING UNCHARGED HYDROPHILIC BLOCK AND CATIONIC POLYAMINO ACID BLOCK HAVING LATERAL CHAIN TO WHICH HYDROPHOBIC RADICAL IS PARTIALLY INTRODUCED, AND USE OF COPOLYMER |
摘要 |
The present invention relates to a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic polyamino acid chain block, wherein the hydrophilic polymer chain block is covalently bound to one end of the main chain of the polyamino acid chain block, and the hydrophobic group is covalently bound to the side chains of not less than 10% and not greater than 70% of amino acid repeating units in the polyamino acid chain block. This block copolymer forms a stable aggregate with siRNA, a small-molecule nucleic acid, under a physiological condition. |
申请公布号 |
EP2272897(B1) |
申请公布日期 |
2016.12.28 |
申请号 |
EP20090720268 |
申请日期 |
2009.03.06 |
申请人 |
The University of Tokyo |
发明人 |
KATAOKA, Kazunori;NISHIYAMA, Nobuhiro;ISHII, Atsushi;KATO, Yasuki;MIYATA, Kanjiiro;KIM, Hyunjin;TAKEMOTO, Hiroyasu |
分类号 |
C08G81/00;C08G69/10;C08L87/00;C08L89/00 |
主分类号 |
C08G81/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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