| 发明名称 |
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| 摘要 |
Substituted bicyclic dihydropyrimidinones of formula 1;
which are inhibitors of neutrophil elastase and useful as medicaments for the treatment of, inter alia, COPD. An exemplary compound is:
; |
| 申请公布号 |
US9475779(B2) |
申请公布日期 |
2016.10.25 |
| 申请号 |
US201514809307 |
申请日期 |
2015.07.27 |
| 申请人 |
Boehringer Ingelheim International GmbH |
发明人 |
Oost Thorsten;Anderskewitz Ralf;Gnamm Christian;Hoesch Holger;Morschhaeuser Gerd;Peters Stefan;Ries Uwe Joerg |
| 分类号 |
C07D239/70;A61K31/517;C07D401/04 |
主分类号 |
C07D239/70 |
| 代理机构 |
|
代理人 |
Morris Michael P.;Lazer Edward S. |
| 主权项 |
1. A compound of formula 1 wherein R1 is R2 is and R3 is H; or R1 is R2 is and R3 is CH3; or R1 is R2 is and R3 is CH3; wherein * indicates the point of attachment; or a pharmaceutically acceptable salt thereof. |
| 地址 |
Ingelheim am Rhein DE |
