| 摘要 |
PROBLEM TO BE SOLVED: To provide formulations for: improving stability of immunogenic compositions; and inhibiting precipitation thereof.SOLUTION: A formulation for stabilizing polysaccharide-protein conjugates comprises: (i) a pH-buffered saline solution, wherein the buffer has a pKa of about 3.5 to about 7.5; (ii) a surfactant; and (iii) one or more polysaccharide-protein conjugates, wherein the formulations are stored in a container selected from one or more of the group comprising a vial, a vial stopper, a vial closure, a glass closure, a rubber closure, a plastic closure, a syringe, a syringe stopper, a syringe plunger, a flask, a beaker, a graduated cylinder, a fermentor, a bioreactor, tubing, a pipe, a bag, a jar, an ampoule, a cartridge and a disposable pen.SELECTED DRAWING: None |
