发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING STIMULATOR OF INTERFERON GENE DEPENDENT SIGNALLING |
摘要 |
The present invention provides cyclic-di-nucleotide (CDN) compounds that inhibit signaling at a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides which inhibit STING-dependent TBK1 activation and the resulting production of type I interferon. |
申请公布号 |
EP2996472(A4) |
申请公布日期 |
2016.12.28 |
申请号 |
EP20140800803 |
申请日期 |
2014.05.18 |
申请人 |
Aduro Biotech, Inc. |
发明人 |
DUBENSKY, Thomas, W., Jr.;KANNE, David, B. |
分类号 |
C07H21/02;A61K31/7084;A61P37/06 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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