发明名称 |
STABLE NANOCOMPOSITION COMPRISING EPIRUBICIN, PROCESS FOR THE PREPARATION THEREOF, ITS USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT |
摘要 |
A nanoparticulate composition is disclosed for the targeted therapeutic treatment of tumours. The stable self assembled nanocomposition according to the invention comprises (i) a carrier and targeting system comprising an optionally modified polyanion, and optionally a polycation, which may also be modified; at least one targeting agent which is linked to either the polycation/modified polycation or the polyanion/modified polyanion, or both; (ii) an active compound selected from the group of epirubicin and its pharmaceutically acceptable salts, especially hydrochloride; and optionally (iii) at least one complexing agent, metal ion and stabilizer/formulating agent. The invention furthermore relates to a process for the preparation of the above-mentioned composition, the therapeutic uses thereof, and pharmaceutical compositions containing the nanocomposition according to the invention. |
申请公布号 |
EP2978428(A4) |
申请公布日期 |
2016.12.28 |
申请号 |
EP20140774311 |
申请日期 |
2014.03.28 |
申请人 |
BBS Nanotechnology Ltd. |
发明人 |
BORBÉLY, János;BERÉNYI, Zsuzsa;HAJDU, István |
分类号 |
A61K47/48;A61K31/455;A61K31/505;A61K31/722;A61K31/728;A61K39/395;A61P35/00;B82Y5/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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