PYRROLO[3,2]PYRIMIDINE DERIVATIVES AS INDUCERS OF HUMAN INTERFERON

摘要

wherein R1 is hydrogen, methyl or —(CH2)2OR3, R2 is methyl or —(CH2)2OR4, or R1 and R2, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl wherein the 6-membered heterocyclyl is optionally substituted by two hydroxy substituents; R3 and R4 are each independently hydrogen or methyl; and n is an integer having a value of 5 or 6, are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment or prevention of various disorders, for example the treatment or prevention of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants.