CHITOSAN NANOFIBER COMPOSITIONS, COMPOSITIONS COMPRISING MODIFIED CHITOSAN, AND METHODS OF USE

摘要

The invention includes chitosan nanofibers having enhanced structural integrity, compositions comprising such chitosan nanofibers, and related methods of use. In a particular aspect, electrospun chitosan nanofibers can be reversibly acylated to enhance structural integrity and promote healing and the formation of tissues in a subject. In another aspect, electrospun chitosan nanofibers comprising at least a portion of the amino groups protected, such as through N-tert-butoxycarbonyl groups, demonstrate enhanced structural integrity and promote healing and the formation of tissues in a subject. The invention also includes compositions and methods for producing a modified chitosan material having anti-inflammatory and pro-healing characteristics and methods of using the modified chitosan materials in a film, a gel, a membrane, microfibers, nanofibers, nano- or micro-particles/spheres and/or sponges. In some aspects, microspheres and methods of producing microspheres comprising modified chitosan are included.

主权项

1. A method of preparing chitosan nanofibers comprising:
electrospinning an acidic solution comprising chitosan into chitosan nanofibers; acylating one or more of the electrospun chitosan nanofibers with an acylating agent; and washing the acylated chitosan nanofibers with a hydrophilic solvent.