DUPA-INDENOISOQUINOLINE CONJUGATES

摘要

A targeting ligand-cytotoxic drug conjugate, for example, a DUPA-Indenoisoquinoline conjugate, is useful for treating cancers, e.g., prostate cancer.

主权项

1. A DUPA-Indenoisoquinoline conjugate represented by formula (IB)
DUPA-Linker-RS-Indenoisoquinoline  (IB)wherein
DUPA is a modified or unmodified 2-[3-(1,3-dicarboxypropyl)-ureido]pentanedioic acid; Linker is a bond, a substituted or unsubstituted alkyl, a peptide, or a peptidoglycan; Indenoisoquinoline is a substituted or unsubstituted indenoisoquinoline; and RS is a release segment capable of releasing Indenoisoquinoline within the desired cells,wherein said release segment is a carbonate segment, a carbamate segment, or an acylhydrazone segment.