| 发明名称 |
BENZOTHIOPHENE DERIVATIVES AS ESTROGEN RECEPTOR INHIBITORS |
| 摘要 |
A compound of formula (I):;;or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor, |
| 申请公布号 |
US2016368911(A1) |
申请公布日期 |
2016.12.22 |
| 申请号 |
US201414898782 |
申请日期 |
2014.07.01 |
| 申请人 |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED |
发明人 |
CAMPOS Sebastien Andre;HARLING John David;MIAH Afjal Hussain;SMITH Ian Edward, David |
| 分类号 |
C07D417/14;C07D413/14;A61K31/422;A61K45/06;C07D471/10;A61K31/435;C07K5/062;A61K38/05;A61K31/427;A61K31/496 |
主分类号 |
C07D417/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of formula (I): Wherein R1 is OH, OC1-3alkyl, halogen, H R2 is OH, OC1-3alkyl X is O, CO L is a linking group comprising a length of 8-16 atoms in shortest length R3 is straight or branched chain C1-6alkyl, C3-6 cycloalkyl R4 is 4-methylthiazol-5-yl, oxazol-5-yl, halo or a pharmaceutically acceptable salt thereof. |
| 地址 |
Brentford, Middlesex GB |
