发明名称 Biorelevant compositions
摘要 This application relates to a homogeneous biorelevant composition for preparing fasted state biorelevant media having a surface tension between 25 mN/m and 50 mN/m for simulating fasted state gastric and fasted state upper small intestinal fluids of mammalian species, especially humans, dogs, etc. comprising at least one bile salt, eg. sodium taurocholate or sodium taurodeoxycholate; at least one phospholipid, especially 60-99 wt% phosphatidylcholine (PC), enzyme digested diacylphospholipids containing 50-90 wt% of monoacyl-PC; or mixtures thereof; and at least one fatty acid or monovalent salt of the fatty acid, such as sodium oleate. The application also relates to an aqueous biorelevant media composed of surfactants occurring in the gastrointestinal tract of mammals, in particular when prepared from above homogeneous biorelevant composition.
申请公布号 NZ700064(A) 申请公布日期 2016.08.26
申请号 NZ20130700064 申请日期 2013.04.02
申请人 PHARES PHARMACEUTICAL RESEARCH N.V. 发明人 LEIGH MATHEW LOUIS STEVEN;LEIGH STEVE;DRESSMAN JENNIFER;KLOEFER BASTIAN;ARNDT MARCEL;FUCHS ALEXANDER
分类号 A61K9/107;G01N33/15;G09B23/28 主分类号 A61K9/107
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