The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
申请公布号
HK1184377(A1)
申请公布日期
2016.09.02
申请号
HK20130111831
申请日期
2013.10.22
申请人
Wyeth LLC
发明人
BERASI, Stephen Peter SP;BROWN, Christopher Todd CT;CAIN, Michael John MJ;CALABRO, Valerie Perrine VP;JUO, Zong Sean ZS;MARTINEZ, Robert Vincent Paul RVP;SEEHERMAN, Howard Joel HJ;WOZNEY, John Martin JM