发明名称 |
MICRO-RNAS OF THE MIR-15 FAMILY MODULATE CARDIOMYOCYTE SURVIVAL AND CARDIAC REPAIR |
摘要 |
A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of cardiomyocytes. Strategies to block expression of the miR-15 family in the heart as a treatment for diverse cardiac disease are provided. |
申请公布号 |
EP2219653(B1) |
申请公布日期 |
2016.12.21 |
申请号 |
EP20080847645 |
申请日期 |
2008.11.10 |
申请人 |
The Board of Regents of The University of Texas System |
发明人 |
OLSON, Eric;VAN ROOIJ, Eva |
分类号 |
A61K31/7088;A01K67/027;A61K31/7105;A61K45/06;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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