| 摘要 |
FIELD: pharmaceutics.SUBSTANCE: invention relates to a compound of formula [I] and its pharmaceutically acceptable salts thereof. Compound of formula [I] possesses renin-inhibitory activity. In formula [I]Ris C-cycloalkyl group; R denotes lower alkyl group or makes 5-6-member ring by binding with Rat each end; T is a carbonyl group; Z is -O-, -NH- or single bond; and R, R, Rand Rare a hydrogen atom. Invention also relates to a pharmaceutical composition containing a compound of the invention, and to a compound of formula [II].EFFECT: obtaining novel compounds of formula [I], having renin inhibitory activity.11 cl, 93 tbl, 422 ex |
