发明名称 |
AMINO ACID-MODIFIED NUCLEIC ACID AND UTILIZATION THEREOF |
摘要 |
Provided is a method for synthesizing a protein, into which a nucleobase amino acid (NBA) is introduced at a desired position, that comprises: a step for preparing mRNA into which a modified codon is inserted at a desired position downstream of an initiation codon; and a step for translating the aforesaid mRNA into a protein in the presence of tRNA, said tRNA recognizing the modified codon and being acylated with the NBA. Also provided is a ribozyme that catalyzes the aminoacylation of tRNA and comprises two RNA molecules. |
申请公布号 |
WO2016199801(A1) |
申请公布日期 |
2016.12.15 |
申请号 |
WO2016JP67025 |
申请日期 |
2016.06.08 |
申请人 |
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY |
发明人 |
KATO, Yoshio;KOJIMA, Naoshi |
分类号 |
C12N15/09;C12N9/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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