发明名称 TABLET FORMULATION FOR CGRP-ACTIVE COMPOUNDS
摘要 The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein "Ra" is independently H or -F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
申请公布号 EP3102564(A1) 申请公布日期 2016.12.14
申请号 EP20150746768 申请日期 2015.01.30
申请人 Merck Sharp & Dohme Corp. 发明人 JOHNSON, Mary Ann;ALLAIN, Leonardo Resende;EICKHOFF, W. Mark;IKEDA, Craig, B.;BROWN, Chad, D.;FLANAGAN, Francis, J., Jr.;NOFSINGER, Rebecca;MAROTA, Melanie;LUPTON, Lisa;PATEL, Paresh, B.;XI, Hanmi;XU, Wei
分类号 C07D221/02;A61K9/26;A61K31/437 主分类号 C07D221/02
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