MOLECULAR DIAGNOSTIC TEST FOR PREDICTING RESPONSE TO ANTI-ANGIOGENIC DRUGS AND PROGNOSIS OF CANCER
摘要
Methods for selecting whether to administer an anti-angiogenic therapeutic agent to a subject include steps of measuring the expression levels of one or more biomarkers selected from Table 2 or Table 3 in a sample from the subject; assessing from the expression levels of the one or more biomarkers whether the sample from the subject is positive or negative for a biomarker signature, wherein if the sample is positive for the biomarker signature an anti-angiogenic therapeutic agent is contraindicated. Related prognostic methods and treatment methods are also provided. The invention is particularly applicable in ovarian and colorectal cancers.
申请公布号
EP3102700(A1)
申请公布日期
2016.12.14
申请号
EP20150705693
申请日期
2015.02.09
申请人
Almac Diagnostics Limited
发明人
HARKIN, Denis Paul;KENNEDY, Richard;KEATING, Katherine E.;MCCAVIGAN, Andrena;HILL, Laura A;DEHARO, Steve;DAVISON, Timothy;PATTERSON, Fionnuala;DONEGAN, Sinead;JELLEMA, Gera;GOURLEY, Charlie