发明名称 |
SUBSTITUTED 4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-a]PYRAZINE DERIVATIVES AND 5,6,7,8-TETRAHYDRO-4H-PYRAZOLO[1,5-a</ i>][1,4]DIAZEPINE DERIVATIVES AS ROS1 INHIBITORS. |
摘要 |
The present invention relates to substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine derivatives and 5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepi ne derivatives of formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as ROS 1 inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. |
申请公布号 |
MX2016012668(A) |
申请公布日期 |
2016.12.14 |
申请号 |
MX20160012668 |
申请日期 |
2015.03.26 |
申请人 |
JANSSEN PHARMACEUTICA NV |
发明人 |
MEERPOEL, Lieven;DESCAMPS, Sophie;MEVELLEC, Laurence Anne;PASQUIER, Elisabeth Thérèse Jeanne;VIALARD, Jorge Eduardo;Berthold WROBLOWSKI;Matthieu Ludovic JEANTY;Thierry François Alain Jean JOUSSEAUME;Guillaume Jean Maurice MERCEY |
分类号 |
C07D487/04;A61K31/519 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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地址 |
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