发明名称 |
PROCESS FOR PURIFYING 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID |
摘要 |
includes the following steps: a) adding an acid to an aqueous solution of the compound of formula 1, including salts and hydrates thereof so as to obtain a slurry having a pH≦3; and b) filtering the slurry and at least one time washing the obtained precipitate with a liquid comprising water; and c) dissolving the precipitate obtained in step b) in water to obtain an aqueous solution; and d) filtering of the solution obtained in step c) over a nanofiltration membrane having a Molecular Weight Cut Off in the range from 150 to 500 and wherein optionally, between step c) and step d) the pH of the aqueous solution is adjusted to a pH value in the pH range as specified by the manufacturer of the nanofiltration membrane. A process for preparing a gadolinium complex of the purified compound of formula 1 is also disclosed. This gadolinium complex can be used for making a pharmaceutical composition as a contrast agent for magnetic resonance imaging. |
申请公布号 |
EP3102566(A1) |
申请公布日期 |
2016.12.14 |
申请号 |
EP20150702255 |
申请日期 |
2015.02.02 |
申请人 |
AGFA Healthcare |
发明人 |
BUFFEL, Diederik;BOI, Xavier;PYPE, Judith |
分类号 |
C07D257/02 |
主分类号 |
C07D257/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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