| 发明名称 |
S1PR2 ANTAGONISTS AND USES THEREFOR |
| 摘要 |
Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) through the administration of a therapeutically effective amount of a sphingosine-1-phosphate receptor type 2 (S1PR2) antagonist. Also provided herein are compounds which contain bioisosteric replacements of the urea group of JTE- 013 and analogs thereof, and their use in treating retinopathies and diseases characterized by insufficient angiogenesis. |
| 申请公布号 |
WO2016191872(A1) |
申请公布日期 |
2016.12.08 |
| 申请号 |
WO2016CA50620 |
申请日期 |
2016.06.01 |
| 申请人 |
DALHOUSIE UNIVERSITY |
发明人 |
MCMASTER, Christopher;SIMMS, Gordon |
| 分类号 |
C07D471/04;A61K31/122;A61K31/196;A61K31/198;A61K31/343;A61K31/353;A61K31/357;A61K31/421;A61K31/444;A61K31/47;A61K31/4709;A61K31/506;A61K31/517;A61K31/566;A61K31/661;A61K31/675;A61P9/10;A61P27/02;C07C50/28;C07C229/24;C07C317/48;C07D215/233;C07D239/91;C07D263/34;C07D307/91;C07D311/58;C07D317/08;C07D405/06;C07F9/141;C07F9/6558;C07J31/00 |
主分类号 |
C07D471/04 |
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