| 摘要 |
An Fe(II) ion detection agent, and related method, capable of fluorescently detecting Fe(II) ions quickly with high sensitivity is disclosed. The Fe(II) ion detection agent can be a compound represented by formula (I) (fluorescence probe):;;wherein R1 and R2 represent lower alkyl; R3 and R4 represent hydrogen; R5 represents hydrogen, hydroxyl, or a group represented by formula (A): —NR51R52 wherein R51 and R52 represent lower alkyl; R6 and R7 represent hydrogen; ring A represents an aromatic ring; V represents O or SiR10R11 wherein R10 and R11 are the same or different and represent, hydrogen or lower alkyl; W represents CH2, CO; Z represents O; m and n are the same or different and represent 0 or 1. The agent can be combined with a compound having at least three coordinating positions. |
| 主权项 |
1. An Fe(II) ion detection agent comprising a compound represented by formula (I): wherein R1 and R2 are the same or different and represent lower alkyl, carboxy lower alkyl, aryl, or aryl lower alkyl; R3 and R4 are the same or different and represent hydrogen, halogen, or lower alkyl; R1 and R2 may be taken together with the nitrogen atom to which they are attached to form a pyrrolidine ring, a piperidine ring, a morpholine ring, or an optionally substituted piperazine ring; R1 and R3 may be taken together to form trimethylene; R2 and R4 may be taken together to form trimethylene; R5 represents hydrogen, optionally protected hydroxyl, lower alkoxy, or a group represented by formula (A): —NR51R52 wherein R51 and R52 are the same or different and represent lower alkyl, carboxy lower alkyl, aryl, or aryl lower alkyl, or R51 and R52 may be taken together with the nitrogen atom to which they are attached to form a pyrrolidine ring, a piperidine ring, a morpholine ring, or an optionally substituted piperazine ring; R6 and R7 are the same or different and represent hydrogen, halogen, or lower alkyl; when R5 is the group represented by formula (A), R51 and R6 may be taken together to form trimethylene, or R52 and R7 may be taken together to form trimethylene; ring A represents an optionally substituted aromatic ring or an optionally substituted heteroaromatic ring; V represents O or SiR10R11 wherein R10 and R11 are the same or different and represent hydrogen or lower alkyl; W represents CH2, CO, or S(O)p; Z represents O or NR9 wherein R9 represents hydrogen or alkyl; m and n are the same or different and represent 0 or 1; and p represents 1 or 2, in combination with a compound having at least three coordinating positions. |
