| 发明名称 |
NOVEL CRYSTALS AND PROCESS OF MAKING 5-(-METHYL)-2-METHOXY-BENZOIC ACID |
| 摘要 |
The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid and methods of making the zwitterion of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid. |
| 申请公布号 |
US2016354389(A1) |
申请公布日期 |
2016.12.08 |
| 申请号 |
US201615171967 |
申请日期 |
2016.06.02 |
| 申请人 |
Forest Tosara Limited |
发明人 |
Anzalone Luigi;Villani Frank J.;Teleha Christopher A.;Feibush Penina;Fegely Barry |
| 分类号 |
A61K31/625 |
主分类号 |
A61K31/625 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a mammal suffering from irritable bowel syndrome, pain or another opioid receptor disorder comprising administering to said mammal an effective amount of a Form β crystal of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid. |
| 地址 |
Dublin IE |
