发明名称 |
THERAPEUTIC VACCINE FOR TREATING OR PREVENTING MERKEL CELL POLYOMA VIRUS-ASSOCIATED TUMORS |
摘要 |
The invention relates to a therapeutic vaccine useful against tumors exhibiting as signature the Large T antigen (LT) of the Merkel Cell PolyomaVirus (MCPyV). Additionally, the therapeutic vaccine may be also useful for preventing tumors in healthy individuals infected with MCPyV. The therapeutic vaccine involves a type-3 secretion system (T3SS) bacterial vector able to deliver a polypeptide comprising LT epitopes to antigen presenting cells (APCs), such as a truncated form of LT. The invention also relates to a fusion protein comprising a truncated form of LT. |
申请公布号 |
EP3101134(A1) |
申请公布日期 |
2016.12.07 |
申请号 |
EP20150305861 |
申请日期 |
2015.06.05 |
申请人 |
Apcure SAS;Altrabio |
发明人 |
BUFFAT, Laurent;PIERINI, Roberto |
分类号 |
C12N15/62;C07K14/025;C12N15/78 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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