发明名称 キノロン化合物
摘要 The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea.
申请公布号 JP6039025(B2) 申请公布日期 2016.12.07
申请号 JP20150168524 申请日期 2015.08.28
申请人 大塚製薬株式会社 发明人 アブゥドゥサイミー、マムゥティー;イエ、ファングオ;スゥン、ジアーンチン;宮本 寿;チェン、ジェイ−フェイ;岡 大輔
分类号 C07D401/04;A61K31/506;A61K31/538;A61P31/04;C07D413/04 主分类号 C07D401/04
代理机构 代理人
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