发明名称 |
COMPOUNDS FOR PROTEASOME ENZYME INHIBITION |
摘要 |
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. |
申请公布号 |
EP3101026(A1) |
申请公布日期 |
2016.12.07 |
申请号 |
EP20160166492 |
申请日期 |
2005.08.08 |
申请人 |
Onyx Therapeutics, Inc. |
发明人 |
SMYTH, Mark S.;LAIDIG, Guy J. |
分类号 |
C07K5/087;A61K38/00;A61K38/04;C07K5/04 |
主分类号 |
C07K5/087 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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