| 发明名称 |
HYBRID DIAZENIUMDIOLATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE IN TREATING CANCER |
| 摘要 |
Disclosed are hybrid compounds that release both nitric oxide and a moiety that inhibits poly (ADP-ribose) polymerase (PARP), e.g., a compound or a pharmaceutically acceptable salt thereof of formula (I), wherein R1-4 and m-p are as described herein. Also disclosed are pharmaceutical compositions and methods of use including treating cancer and enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation. |
| 申请公布号 |
EP2768824(B1) |
申请公布日期 |
2016.12.07 |
| 申请号 |
EP20120841601 |
申请日期 |
2012.10.18 |
| 申请人 |
The United States of America, as Represented by The Secretary, Department of Health and Human Services |
发明人 |
MACIAG, Anna E.;KEEFER, Larry K.;SAAVEDRA, Joseph E.;JI, Xinhua;KUMARI, Vandana |
| 分类号 |
C07D403/10;A61K31/496;A61P35/00;C07D237/26;C07D241/04 |
主分类号 |
C07D403/10 |
| 代理机构 |
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代理人 |
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