FREMGANGSMÅDE TIL FREMSTILLING AF DITHIIN-TETRACARBOXIMIDER

摘要

Preparing dithiine tetracarboximide compounds (I), comprises (a) reacting succinic monoamide compounds (VI) with thionyl chloride to give a reaction mixture, (b) heating the obtained mixture and (c) converting the reaction mixture to form dithiine tetracarboximide, where at least one of the method steps is carried out continuously. Preparing dithiine tetracarboximide compounds of formula (I), comprises (a) reacting succinic monoamide compounds of formula (HO-C(=O)-(CH 2) 2-C(=O)-NH-R) (VI) with thionyl chloride to give a reaction mixture, (b) heating the obtained mixture, and (c) converting the reaction mixture to form dithiine tetracarboximide, where at least one of the method steps is carried out continuously. R1, R2 : 1-8C alkyl (optionally substituted with one or more halo, -OR3 or -COR4), 3-7C cycloalkyl (optionally substituted with one or more halo or 1-4C (halo)alkyl), (aryl)-1-4C alkyl (optionally substituted with one or more halo, 1-4C (halo)alkyl, -COR4 or sulfonylamino), or H; R3 : H, 1-4C (alkyl)carbonyl or aryl (optionally substituted with one or more halo or 1-4C (halo)alkyl); R4 : OH, 1-4C alkyl or 1-4C alkoxy; and R : R1 or R2 with an excess of thionyl chloride. [Image] ACTIVITY : Anthelmintic; Nematocide. MECHANISM OF ACTION : None given.