| 发明名称 | Engineered polypeptides having enhanced duration of action | ||
| 摘要 | Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including obesity and overweight, diabetes, dyslipidemia, hyperlipidemia, Alzheimer's disease, fatty liver disease, short bowel syndrome, Parkinson's disease, cardiovascular disease, and other and disorders of the central nervous system. | ||
| 申请公布号 | US9593154(B2) | 申请公布日期 | 2017.03.14 |
| 申请号 | US201313852899 | 申请日期 | 2013.03.28 |
| 申请人 | AstraZeneca Pharmaceuticals LP;Amylin Pharmaceuticals, LLC | 发明人 | Erickson Mary;Litzinger David C.;Ghosh Soumitra S.;Guo Zijian;Neravetla Swetha;Sun Chengzao;Samant Manoj P.;Levy Odile E.;Sharma Abhinandini;Mamedova Lala;Soares Christopher J. |
| 分类号 | C07K14/605;A61K47/48;C07K14/575 | 主分类号 | C07K14/605 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. |
| 主权项 | 1. A polypeptide comprising the amino acid sequence of SEQ ID NO:95. | ||
| 地址 | Wilmington DE US | ||