Bicyclic agonists of GPR131 and uses thereof

摘要

The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments, the structure of the compounds is given by Formula I:;
wherein the variables are as described herein. Related compositions, formulations and methods for the preparation of compounds of formula I are also described.

主权项

1. A compound of formula (I)or a derivative thereof, wherein
A is an optionally substituted aryl or heteroaryl; D1 and D2 are each independently C or N; and D3, D4, and D5 are each independently CR2, N, NR8, or O, wherein D1, D2, D3, D4, and D5 together form Het2, which is an optionally substituted 5-membered heteroaryl; E is alkyl, aryl, arylalkyl, cycloalkyl, heteroalkyl, heteroaryl, or heterocycloalkyl, each of which may be optionally substituted,is selected from the group consisting ofand
R2 is independently H, alkoxy, optionally substituted C1-6alkyl, amido, amino, cyano, halo, hydroxyl, sulfonyl, or sulfonamido; and R8 is H or optionally substituted C1-6alkyl.