发明名称 | Method for the preparation of diazoalkanes | ||
摘要 | The present invention relates to a method of forming diazoalkanes. One aspect of the present invention provides a method for the production of a N-alkyl-N-nitroso compound from a starting material, comprising the use of a tribasic acid to acidify an amine. A second aspect of the present invention provides a method for the production of a diazoalkane, comprising reacting a N-alkyl-N-nitroso compound with a base and a phase transfer catalyst, wherein no organic solvent is used. | ||
申请公布号 | US9593073(B2) | 申请公布日期 | 2017.03.14 |
申请号 | US201314373828 | 申请日期 | 2013.01.23 |
申请人 | BAKHU LIMITED | 发明人 | Proctor Lee |
分类号 | C07C245/16;C07C241/00;C07C243/04 | 主分类号 | C07C245/16 |
代理机构 | Brinks Gilson & Lione | 代理人 | Brinks Gilson & Lione |
主权项 | 1. A method for the production of a diazoalkane, comprising reacting an N-alkyl-N-nitroso compound with a base and a phase transfer catalyst in a reaction mixture, wherein no organic solvent is used;the phase transfer catalyst is selected from the group consisting of quaternary ammonium salts and phosphonium salts;the N-alkyl-N- nitroso compound has the general formula: wherein RI, R2, R3 and R4 are hydrogen, alkyl, alkenyl, alkoxy, alkoxylate, alkyloxy, alkenyloxy or alkoxyalkyl groups, R6 is an alkyl group and R5 is hydrogen or an alkyl group; and an organic by-product which is formed during diazoalkane production separates from the reaction mixture as a discrete phase, and wherein said base is present in aqueous solution at a concentration of between 10% and 50%. | ||
地址 | Southport GB |