发明名称 |
Monoclonal antibodies against antithrombin β |
摘要 |
This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ATβH). These ATβH binding proteins can block the anti-coagulant activity of ATβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies. |
申请公布号 |
US9593166(B2) |
申请公布日期 |
2017.03.14 |
申请号 |
US201414214382 |
申请日期 |
2014.03.14 |
申请人 |
BAYER HEALTHCARE LLC |
发明人 |
Jin Ye;Murphy John E.;Hermiston Terry;Myles Timothy;Dittmer Frank;Strerath Michael;Gritzan Uwe |
分类号 |
C07K16/18;A61K45/06;A61K39/395;C07K16/36;A61K38/48;C07K16/38 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
1. A monoclonal antibody capable of binding AtβH, wherein the heavy chain of said antibody comprises: a HCDR1 comprising SEQ ID NO: 40, a HCDR2 comprising SEQ ID NO: 45, and a HCDR3 comprising SEQ ID NO: 50; and
wherein the light chain of said antibody comprises: a LCDR1 comprising SEQ ID NO: 21, a LCRD2 comprising SEQ ID NO: 26, and a LCDR3 comprising SEQ ID NO: 31. |
地址 |
Whippany NJ US |