28 kDa GST proteins from schistosoma for the use thereof in the treatment of inflammatory autoimmune diseases generating a Th1 and/or Th17 response

摘要

The present invention relates to a product selected from a protein, a fragment of the protein, a derived sequence and a homologous sequence of the protein, the protein including or being constituted by the 28 kDa glutathione S-transferase protein from a schistosome selected from Schistosoma haematobium, Schistosoma mansoni, Schistosoma bovis represented respectively by the sequences SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3 for the use thereof in the treatment of an inflammatory autoimmune disease generating a response of type Th1 and/or Th17.

主权项

1. A method of preventing and/or therapeutically treating a chronic inflammatory disease connected with an immune system disorder generating an immune response of type Th1/Th17, comprising administering to a subject in need thereof an effective amount of a product consisting of a protein, thereby leading to the induction of a Th2 response and/or the decrease of the Th1 response, wherein:
said protein comprises or is constituted by the 28 kDa glutathione S-transferase protein from a schistosome selected from the group consisting of Schistosoma haematobium, Schistosoma mansoni, and Schistosoma bovis represented by the sequences SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3, respectively.