Combination unit dose dispensing containers

摘要

Dosage forms containing pharmaceutical compositions for use in devices to produce a spray or mist delivery of the compositions include dosage blister compartments and a dispensing blister compartment, wherein crushing of the compartments delivers the compositions in a desired spray pattern. Certain dosage forms include a plurality of dosage chambers each containing a component or a portion of a pharmaceutical composition, the contents of which are mixed or combined just prior to or during administration.

主权项

1. An internally pierced formed blister comprising:
a blister formed from a stretched flexible film material into a recess with an open end; a piercable surface sealed to the open end of the blister to form an internal chamber enclosed by the formed recess; and a piercing nozzle wholly contained in the internal chamber, the piercing nozzle comprising a base, a tapered hollow elongated body, projecting from the base at a first end, and forming an internal channel and a discharge nozzle at a second end opposite the base, and comprising structural features on the surface of the internal channel to control the spray pattern and droplet size of a fluid forced to flow through the piercing nozzle under pressure, and one or more inlet openings and channels providing a fluid path from the internal chamber through the base and into the internal channel of the piercing nozzle and out the discharge nozzle.