Photometric enthalpy change detection system and method

摘要

A method for detecting an enthalpy change includes providing a first mixture and a second mixture to a drop generator. The first mixture includes a ligand. The second mixture contains a target molecule. The method further includes generating a drop in the drop generator. The drop includes the target molecule, a temperature-sensitive reporter compound, and the ligand. The method also includes measuring a property of the temperature-sensitive reporter compound in the drop to determine an amount of enthalpy change that has occurred.

主权项

1. A method for performing calorimetry comprising:
providing a first mixture comprising a first portion of a first fluid and a ligand to a drop generator; providing a second mixture comprising a second portion of the first fluid and a target molecule to the drop generator; generating a drop in a second fluid, wherein the first fluid and the second fluid are immiscible, the drop comprising the target molecule, a temperature-sensitive reporter compound, and the ligand; and measuring a temperature of the drop over time by measuring a property of the temperature-sensitive reporter compound to perform calorimetry.