| 主权项 |
1. A compound of formula IA:wherein
Pn is a polymer chain, E is a chain extension residue corresponding to formula E3 j, k and l are each independently selected integers, where j ranges from 0 to 9, k is >1, l ranges from 0 to 9, and the sum (j+k+l) is <10, L is a linking moiety, Q is a biomolecular agent covalently bonded through L to R5 of chain extension residue E, the biomolecular agent being a therapeutic agent, a targeting agent, a diagnostic agent, or an analytical agent, R1 and R4 are each hydrogen, R2, N—R5, and R3 together form an N-substituted imidyl moiety represented by the formula —C(O)NR5C(O)—, R5 is a C1-C20 moiety comprising a functional group or comprising a functional group covalently coupled to the biomolecular agent, Q, through a linking moiety, L, wherein the C1-C20 moiety is selected from the group consisting of hydrocarbyl, substituted hydrocarbyl, hetero-hydrocarbyl, substituted hetero-hydrocarbyl, carbocyclic, substituted carbocyclic, heterocyclic, substituted heterocyclic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and fused-multiring structures comprising one or more of the foregoing, and wherein the functional group is selected from the group consisting of amino, ammonio, imino, amido, imidyl, nitrile, azo, azido, cyano, cyanato, isocyanato, isothiocyanto, hydrazide, nitro, nitroso, nitrosooxy, pyridyl, hydroxyl, alkoxy, carboxyl, ester, acyl, halo, haloformyl, phosphino, phosphoric, phospho, sulfide, di-sulfide, thio, thiol, sulfonyl, sulfo, sulfinyl, alkenyl, alkynl, allenyl, and silyl, and Y is a thiocarbonylthio moiety having a formula —SC(═S)Z, where Z is an activating group. |
