Methods and compositions for pre-screening patients for treatment with noribogaine

摘要

This invention is directed to a method for pre-screening an opioid-addicted patient to determine the patient's tolerance for a therapeutic dose of noribogaine.

主权项

1. A method for screening an opioid-addicted patient to determine the patient's tolerance for a therapeutic dose of noribogaine or pharmaceutically acceptable salt and/or solvate thereof, the method comprising:
measuring the patient's pre-administration QT interval; administering orally or by direct blood stream delivery to the patient a sub-therapeutic dose of 60 mg to 100 mg of noribogaine or pharmaceutically acceptable salt thereof; measuring the patient's post-administration QT interval; and comparing the difference between the pre-administration QT interval and post-administration QT interval with an expected change in QT interval for the dose administered based on a known average change in QT interval for the sub-therapeutic dose, wherein the patient is tolerant of a therapeutic dose of noribogaine or pharmaceutically acceptable salt and/or solvate thereof if the difference is not more than the expected change.