Ionizable cationic lipid for RNA delivery

摘要

What is described is a compound of formula (1);
wherein
R1 and R2 are the same or different, each a linear or branched alkyl with 1-9 carbons, or an alkenyl or alkynyl with 2 to 11 carbon atoms;L1 and L2 are the same or different, each a linear alkyl having 5 to 18 carbon atoms, or form a heterocycle with N;X1 is a bond, or is —CO—O— whereby L2-CO—O—R2 is formed;X2 is S or O; L3 is a bond or a lower alkyl, or form a heterocycle with N;R3 is a lower alkyl; and R4 and R5 are the same or different, each a lower alkyl;

or a pharmaceutically acceptable salt thereof.

主权项

1. A compound of formulawherein
R1 and R2 are the same or different, each a linear or branched alkyl consisting of 1 to 9 carbons, an alkenyl or alkynyl consisting of 2 to 11 carbons, or cholesteryl, L1 and L2 are the same or different, each a linear alkylene or alkenylene consisting of 5 to 18 carbons, X1 is —CO—O— whereby -L2-CO—O—R2 is formed, X2 is S or O, X3 is —CO—O— whereby -L1-CO—O—R1 is formed, L3 is a bond, R3 is a linear or branched alkylene consisting of 1 to 6 carbons, and R4 and R5 are the same or different, each hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons;or a pharmaceutically acceptable salt thereof.