Syringes for repetitive mixing and delivery of injectables

摘要

Mixing syringes including a valve mechanism are configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for the mixing of one or more substances, and the resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject. The repetitive mixing of substances contained in a distal and proximal chamber is also provided, where the plunger rod is configured to releasably engage a locking mechanism to actuate the valve, and can axially displace the distal seal assembly while the fluid passage is open.

主权项

1. A prefillable repetitive mixing syringe for administration of at least one substance comprising
a syringe housing; a distal seal assembly axially displaceably disposed within the housing, wherein the position of the distal seal assembly defines a mutable distal chamber and a mutable proximal chamber within the housing; the distal seal assembly further comprising a valve that regulates a fluid passage between the proximal and distal chambers; a proximal seal; a connector configured to connect irreversibly the proximal seal and the distal seal assembly, wherein the connected proximal seal and distal seal assembly translate axially together within the housing; and a plunger rod positioned coaxially within the syringe housing and engaged with the distal seal assembly, wherein the plunger rod is configured to releasably engage a locking mechanism to actuate the valve, and whereby the plunger rod can axially displace the distal seal assembly while the fluid passage is open.