Delivery of two or more medicaments through a single dose selection and dispense interface

摘要

An injection system for co-delivery of two medicaments (1, 2) having a drug delivery device (7) containing a primary reservoir (11) containing a first medicament (1) and having a secondary reservoir (5, 17, 30) containing a second medicament (2) where the drug delivery device (7) has only one dose setter (12) for the primary reservoir (11) and that automatically determines the dose of the second medicament (2). Both medicaments (1, 2) are delivered through a single dispense interface (3, 16, 21, 31).

主权项

1. A drug delivery system operable to deliver a first medicament and a second medicament through a single dispense interface, comprising:
a primary drug delivery device comprising:
a primary reservoir containing the first medicament, wherein the first medicament comprises at least one first drug agent, and wherein the primary reservoir comprises a pierceable seal, anda dose button operably connected to the primary reservoir; and a medicated module configured to be attached to a distal end of the primary drug delivery device, the medicated module comprising:
an engagement interface configured such that attachment of the medicated module to the distal end of the primary drug delivery device causes the engagement interface to pierce the pierceable seal of the primary reservoir,a dispense interface configured for fluid communication with the primary reservoir via the engagement interface, anda secondary reservoir containing the second medicament, wherein the second medicament comprises at least one second drug agent, and wherein the secondary reservoir is configured for fluid communication with the dispense interface, wherein the medicated module is configured such that when the medicated module is attached to the distal end of the primary drug delivery device, a single activation of the dose button causes the first medicament from the primary reservoir and a non-user settable dose of the second medicament to be expelled through the dispense interface, and where the single activation of the dose button causes the first medicament from the primary reservoir to be expelled through the dispense interface after a therapeutic dose of the non-user settable dose of second medicament has been expelled through the dispense interface.